| 세션명 | 의료용 고분자 부문위원회(III) |
|---|---|
| 발표장 | 포스터장 |
| 논문코드 | 3PS-301 |
| 발표일 | 2018-10-12 |
| 발표시간 | 16:00-17:30 (게시시간: 14:00-17:30) |
| 논문제목 | H2O2-Activatable and CO2 Bubble Generating Theranostic Agents for Peripheral Artery Disease |
| 발표자 | 현혜진 |
| 발표자 소속 | 전북대학교 |
| 저자 | 현혜진, 이동원†, 노정연, 고창곤, 이하늬 |
| 소속 | 전북대학교 |
| 논문초록 | Peripheral artery disease (PAD) is one of the life-threatening vascular diseases that characterized by vascular obstruction, causing ischemia in the hindlimb and reducing blood flow and oxygen supply to the tissues. Ischemic tissues are under oxidative stress associated with significantly high level of reactive oxygen species (ROS) including hydrogen peroxide (H2O2). In this work, we developed H2O2-responsive curcumin-loaded PVAX (CUR-PVAX) nanoparticles which could release bioactive curcumin, vanillyl alcohol and CO2 bubbles in a H2O2-triggered manner. In vivo studies, CUR-PVAX nanoparticles exhibited potent therapeutic actions by suppressing oxidative stress and pro-inflammatory cytokines and enhancing angiogenic factors such as VEGF. In addition, CUR-PVAX nanoparticles displayed enhanced ultrasound contrast by generation of CO2. Herein, we anticipate that CUR-PVAX nanoparticles hold a great translational potential as theranostic agents for ischemic diseases such as PAD. |
THE POLYMER SOCIETY OF KOREA